Antidiabetic potential of Moringa oleifera Lam. leaf extract in type 2 diabetic rats, and its mechanism of action

Purpose: To explore the antidiabetic potential of Moringa oleifera leaf extract in type 2 diabetic rats, and underlying mechanisms.Methods: Streptozotocin (STZ) at a dose 40 mg/kg was given to high fat diet (HFD)- fed rats induce diabetes. M. doses 100, 200 400 were 3 groups rats. The area under curve (AUC) glucose homeostasis model assessment insulin resistance (HOMA-R) calculated using appropriate formulas, whereas levels glucose,insulin, peroxisome proliferator activated receptor-? (PPAR?, dipeptidyl peptidase-IV (DPP-IV) inflammatory cytokines (IL-6, IL-1? TNF?) assayed ELISA kits.Results: significantly reduced glucose, treated (p < 0.05). DC group had increased AUC for extract-treated showed significant decrease AUC. There sensitivity parameters, as indicated by increase HOMA-R PPAR? However, treatment with reversed this trend via marked level rise level. In contrast, no effect on DPP-IV concentration 0.05).Conclusion: These results indicate that mitigates hyperglycemia DM modulating hyperinsulinemia, cytokines. Thus, is source drug management DM.
 Keywords: oleifera, Diabetes mellitus, Streptozotocin, Peroxisome receptor-?, Dipeptidyl peptidase IV